Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia
Identifieur interne : 002282 ( Main/Exploration ); précédent : 002281; suivant : 002283Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia
Auteurs : Claudia Schwab [Canada] ; C. Steele ; Haruhiko Akiyama [Japon] ; G. Mcgeer [Canada] ; L. Mcgeer [Canada]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1995-09-01.
Abstract
Abstract: The Chamorro population of the island of Guam is highly susceptible to a disease called lytico-bodig (LB), wich clinically resembles a mixture of amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer disease (AD). The disease is characterized by the widespread development of neurofibrillary tangles in the central nervous system. These tangles have an immuno-histochemical profile indistinguishable from that seen in AD. We studied by immunohistochemistry the occurrence of intracellular and extracellular neurofibrillary tangles in LB in the entorhinal cortex, hippocampus and substantia nigra using antibodies to tau protein and ubiquitin. We also studied the relationship of these tangles to amyloid precursor protein (APP) and its β-amyloid fragment (BAP), using multiple antibodies to BAP and other APP sequences. In advanced cases of LB, the development of neurofibrillary tangles was far more severe than in advanced cases of AD. Virtually all neurons of CA-1 and the subiculum were lost and only ghost tangles remained. In areas dominated by such extracellular tangles, BAP deposits were frequently observed developing around the fibers of ghost tangles. In some cases, the deposits covered only a few of the fibers, but in others, they seemed to envelope the complete tangle. The deposits were thiolavin S and Congo red positive, indicating that the BAP was in a consolidated form. We describe these entities as tangle-associated amyloid deposits”. Such BAP deposits have previously eeen described in some cases of AD, dementia pugilistica and LB. However, we found them in all cases of LB with dementia in the hippocampal-entorhinal areas and in most cases in the substantia nigra. They do not evolve from diffuse BAP deposits since they are remote from them, and they do not trap dystrophic neurites. The fact that extracellular tangle material can act as a nidus for BAP build-up in LB suggests that further consideration needs to be given to the ways in which extracellular BAP deposits are formed.
Url:
DOI: 10.1007/BF00296513
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia</title><author><name sortKey="Schwab, Claudia" sort="Schwab, Claudia" uniqKey="Schwab C" first="Claudia" last="Schwab">Claudia Schwab</name></author><author><name sortKey="Steele, C" sort="Steele, C" uniqKey="Steele C" first="C." last="Steele">C. Steele</name></author><author><name sortKey="Akiyama, Haruhiko" sort="Akiyama, Haruhiko" uniqKey="Akiyama H" first="Haruhiko" last="Akiyama">Haruhiko Akiyama</name></author><author><name sortKey="Mcgeer, G" sort="Mcgeer, G" uniqKey="Mcgeer G" first="G." last="Mcgeer">G. Mcgeer</name></author><author><name sortKey="Mcgeer, L" sort="Mcgeer, L" uniqKey="Mcgeer L" first="L." last="Mcgeer">L. Mcgeer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:44214C3940254DF77F60D59F55A5025CA0C70D26</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1007/BF00296513</idno><idno type="url">https://api.istex.fr/document/44214C3940254DF77F60D59F55A5025CA0C70D26/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002083</idno><idno type="wicri:Area/Main/Curation">001D82</idno><idno type="wicri:Area/Main/Exploration">002282</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia</title><author><name sortKey="Schwab, Claudia" sort="Schwab, Claudia" uniqKey="Schwab C" first="Claudia" last="Schwab">Claudia Schwab</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1Z3, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name sortKey="Steele, C" sort="Steele, C" uniqKey="Steele C" first="C." last="Steele">C. Steele</name><affiliation><wicri:noCountry code="subField">Guam</wicri:noCountry></affiliation></author><author><name sortKey="Akiyama, Haruhiko" sort="Akiyama, Haruhiko" uniqKey="Akiyama H" first="Haruhiko" last="Akiyama">Haruhiko Akiyama</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Institute of Psychiatry, Psychiatry Research Institute of Tokyo), 4-8, Kamikitazawa, Setagaya-ku, 156, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Mcgeer, G" sort="Mcgeer, G" uniqKey="Mcgeer G" first="G." last="Mcgeer">G. Mcgeer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1Z3, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name sortKey="Mcgeer, L" sort="Mcgeer, L" uniqKey="Mcgeer L" first="L." last="Mcgeer">L. Mcgeer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1Z3, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1995-09-01">1995-09-01</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="287">287</biblScope><biblScope unit="page" to="298">298</biblScope></imprint><idno type="ISSN">0001-6322</idno></series><idno type="istex">44214C3940254DF77F60D59F55A5025CA0C70D26</idno><idno type="DOI">10.1007/BF00296513</idno><idno type="ArticleID">Art10</idno><idno type="ArticleID">BF00296513</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The Chamorro population of the island of Guam is highly susceptible to a disease called lytico-bodig (LB), wich clinically resembles a mixture of amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer disease (AD). The disease is characterized by the widespread development of neurofibrillary tangles in the central nervous system. These tangles have an immuno-histochemical profile indistinguishable from that seen in AD. We studied by immunohistochemistry the occurrence of intracellular and extracellular neurofibrillary tangles in LB in the entorhinal cortex, hippocampus and substantia nigra using antibodies to tau protein and ubiquitin. We also studied the relationship of these tangles to amyloid precursor protein (APP) and its β-amyloid fragment (BAP), using multiple antibodies to BAP and other APP sequences. In advanced cases of LB, the development of neurofibrillary tangles was far more severe than in advanced cases of AD. Virtually all neurons of CA-1 and the subiculum were lost and only ghost tangles remained. In areas dominated by such extracellular tangles, BAP deposits were frequently observed developing around the fibers of ghost tangles. In some cases, the deposits covered only a few of the fibers, but in others, they seemed to envelope the complete tangle. The deposits were thiolavin S and Congo red positive, indicating that the BAP was in a consolidated form. We describe these entities as tangle-associated amyloid deposits”. Such BAP deposits have previously eeen described in some cases of AD, dementia pugilistica and LB. However, we found them in all cases of LB with dementia in the hippocampal-entorhinal areas and in most cases in the substantia nigra. They do not evolve from diffuse BAP deposits since they are remote from them, and they do not trap dystrophic neurites. The fact that extracellular tangle material can act as a nidus for BAP build-up in LB suggests that further consideration needs to be given to the ways in which extracellular BAP deposits are formed.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Steele, C" sort="Steele, C" uniqKey="Steele C" first="C." last="Steele">C. Steele</name></noCountry><country name="Canada"><noRegion><name sortKey="Schwab, Claudia" sort="Schwab, Claudia" uniqKey="Schwab C" first="Claudia" last="Schwab">Claudia Schwab</name></noRegion><name sortKey="Mcgeer, G" sort="Mcgeer, G" uniqKey="Mcgeer G" first="G." last="Mcgeer">G. Mcgeer</name><name sortKey="Mcgeer, L" sort="Mcgeer, L" uniqKey="Mcgeer L" first="L." last="Mcgeer">L. Mcgeer</name></country><country name="Japon"><noRegion><name sortKey="Akiyama, Haruhiko" sort="Akiyama, Haruhiko" uniqKey="Akiyama H" first="Haruhiko" last="Akiyama">Haruhiko Akiyama</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002282 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002282 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:44214C3940254DF77F60D59F55A5025CA0C70D26
|texte= Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia
}}
| This area was generated with Dilib version V0.6.23. |  |